![]() However, the methodological quality of the existing RCT evidence base is uncertain. Topical anaesthetics appear more effective than placebo, paroxetine and sildenafil at increasing IELT in men with PE. Diverse methods of assessing sexual satisfaction and ejaculatory control with topical anaesthetics are reported and evidence is conflicting. More systemic adverse events are reported with tramadol, sildenafil and paroxetine than with lidocaine gel. TEMPE spray is associated with significantly more adverse events than placebo ( P = 0.003). Individual RCT evidence also suggests that Topical Eutectic-like Mixture for Premature Ejaculation (TEMPE) spray and lidocaine gel are both significantly more effective than placebo ( P = 0.003 P < 0.00001) and lidocaine gel is significantly more effective than sildenafil or paroxetine ( P = 0.01 P = 0.0001). Pooled evidence (two RCTs, 43 participants) suggests that EMLA is significantly more effective than placebo at increasing IELT ( P < 0.00001). ![]() Seven were of unclear methodological quality. Between-trial heterogeneity was assessed. IELT and other outcomes were pooled across RCTs in a meta-analysis. Methodological quality of RCTs was assessed. The spray is quite helpful for men who suffer from premature ejaculation. Lidocaine has several applications and one of the most common ones is in the form of lidocaine spray. The primary outcome was intra-vaginal ejaculatory latency time (IELT). Here are some of the best over-the-counter creams for lidocaine Strongest Lidocaine Cream OTC. Bibliographic databases including MEDLINE were searched to August 2014. The purpose of this systematic review was to evaluate the evidence from randomised controlled trials (RCTs) for topical anaesthetics in the management of PE. Summary: This study aimed to evaluate the efficacy and safety of applying 5 lidocaine cream to the sensitive area of the glans penis after its precise. Other topical anaesthetics are available, some of which have been evaluated against oral treatments. Eutectic Mixture of Local Anaesthetics (EMLA) is recommended for use off-label as a treatment for premature ejaculation (PE).
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